Editorial: Alfred Pingoud (1945–2015)

Specificity changes in the evolution of type II restriction endonucleases: a biochemical and bioinformatic analysis of restriction enzymes that recognize unrelated sequences.

How restriction enzymes with their different specificities and mode of cleavage evolved has been a long standing question in evolutionary biology. We have recently shown that several Type II restriction endonucleases, namely SsoII (downward arrow CCNGG), PspGI (downward arrow CCWGG), Eco-RII (downward arrow CCWGG), NgoMIV (G downward arrow CCGGC), and Cfr10I (R downward arrow CCGGY), which reco...

Tropical Pyomyositis (Bung-Pagga's Disease) *Paper has been rearranged by the editorial office.

Evolutionary relationship between different subgroups of restriction endonucleases.

The type II restriction endonuclease SsoII shows sequence similarity with 10 other restriction endonucleases, among them the type IIE restriction endonuclease EcoRII, which requires binding to an effector site for efficient DNA cleavage, and the type IIF restriction endonuclease NgoMIV, which is active as a homotetramer and cleaves DNA with two recognition sites in a concerted reaction. We show...

One Hundred and Fourteen Cases of Typhus Fever Seen in an Indian Military Hospital in Calcutta

many cases have been seen both in British and Indian troops. As Dr. Napier pointed out (Editorial, 1936 ; Napier, 1943) the ' detecting power' of troops for disease, when they are introduced into India, is considerable. They need not be British troops. Indian troops when moved outside their own areas are prone to pick up disease to which they have not been exposed in their own country. The case...

Sulphanilyl Benzamide in the Treatment of Bacillary Dysentery *This paper and this subject are discussed in an editorial in our next number.—Editor.

. 0ttietimes it causes vomiting and thus its use ?ften precluded in cases which need it most hughes, 1944). Symptoms such as rashes^ Nausea, headache, tachycardia and fever are ^ uncommon (Smith, 1944; Brewer, 1943). f"e dosage used is usually large?an adult ?* average weight requiring a total dose ot at least 100 to 116 tablets of 0.5 gramme ?ach (Clay, 1943). Moreover, sulphaguanidine 15 ft?t...